Just my various thoughts on my main areas of interest: mind, brain functions, consciousness, technology, travel, food, hamburgers, wine, champagne, high-end hotels, frequent flyer programs, credit card programs, cheap philosophy (the kind that you would not spend money to read) etc... It's all written in English by a French culture shifter living in France. This blog also features hamburger photography, food porn & absurdity. It may be offensive to intellectuals & aesthetes.
Saturday, October 16, 2010
Our Alternate Plane Of Existence
As members of a biological species, we are all made of organs, cells, molecules and atoms. The specificity of biological species is that they reproduce and are in constant re-arrangement of the matter that they are made of. Every second, millions of cells in our body die and are replaced by brand new ones that are made of reprocessed biological material. This never-ending (at the phylogenetic level) recycling machinery has been at work for at least 3.5 billion years on our planet.
Being in this constant re-arrangement state and spreading our molecules around us seem to have given birth to our ontogenetic desire to leave traces of our existence after our death. One could consider that artistic expression, literature, accomplishments in sports etc... are no more than a mere unconscious attempt at fulfilling our phylogenetic programming at the ontogenetic level.
Recent advances in technologies have had a profound impact on this aforementioned process. We are now all leaving traces of our existence everywhere. This is not restricted to the Elite anymore. And the most fascinating aspect of this phenomenon is that the traces we leave are not only non-biological (we don't spread dead cells around us) or static (when it comes to writing on paper in the attempt to reach literature fame), they are capable of self-reproduction. As a matter of fact, all the tweets we send are instantaneously sent to thousands of computers, stored locally or just passed on to another computer. They continue to exist on hard drives after they have disappeared from the user searchable information. Consequently, all the information that originates from us is transcended to a silicon plane of existence where it will continue a life of its own. We have to be aware that our pictures, videos, texts end up in the primordial silicon soup that is the Internet. I see in this realization a very close parallel to the primordial soup that was once the cradle of life on Earth. Could it be at the origin of a new type of life or for that matter intelligent life? Could it be at origin of a digital double of each and everyone of us?
I can't wait for my digital double to taste a digital hamburger!
David Blaine & 17 mins
Pushing human limits even further, David Blaine managed to hold his breath for 17 minutes! 17 minutes! Another must-see TEDTalk! Enjoy it!
Labels:
17 minutes,
Breath,
David Blaine,
Hold,
Magician,
Record
The Legion Of eXtraordinary Dancers (LXD)
This is one my favorite TEDTalks! The way these people dance is just out-of-this-worldish. They give us the eerie impression that they are able to manipulate matter, energy and time through their flawless skills. This probably is the exact opposite of Theoretical Physics but it gives us a deep understanding of how first-hand experience can be misleading. Nobody would indeed think that what is presented here is actually possible to achieve and yet, the proof is right there in front of our eyes! Enjoy it!
Je Suis Une Saucisse De Strasbourg (JFK 101)
As I recently visited the beautiful, though medieval with a touch of 1960s ugly architecture, city of Strasbourg, I couldn't help myself thinking of what President JFK might have said, had he visited Alsace instead of Berlin in 1963.
His famous words "Ich Bin Ein Berliner" which literally translate in German as "I am a jelly-filled doughnut" could have been in French: "Je suis une saucisse de Strasbourg" (I am a Strasbourger sausage). I believe my ever-growing French audience might find that amusing.
Evidently, I cannot end this post without making a reference to numbers as my thoughts for JFK are, I believe, no coincidence. I was born on the exact same day that JFK was shot in Dallas (Granted I'm talking about the exact same day in a different year) which probably makes me the only person in the entire universe to share this in common with him. Last but not least, the last 6 digits of my phone number in Neverland correspond to the date of his death. Are you superstitious?
Friday, October 15, 2010
Capitalism, Human Nature, Technocracy, New World Order & Martinis
Today I received in the mail a special invitation from "The Economist" newspaper. It said that I could receive 4 issues for free and then decide if I wanted to subscribe or not. Since I have no knowledge whatsoever in this field, nor am I the least bit interested in it (as I'd rather spend my free time dreaming up new hamburgers), I thought it was a divine sign and that by touching the envelope this invitation came in, I would absorb all knowledge related to economy through osmosis. That being said, I am now in a position to analyse with the utmost subtlety our world and its economy.
First of all, let me state that I am a true believer in the virtues of Capitalism as it is probably the most suited economical system ever invented to this date. Its strength lies in the fact that it is compatible with human nature. Contrary to what great minds and philosophers (who, by the way, never had the guts to venture in the hamburger literature) would like to think, human beings aren't benevolent by nature. They tend to be greedy, selfish and most of all short-sighted. I read Karl Marx (and loved his cousins' movies) and I do think that his theories sound great but they are, in no way, compatible with human nature. Just look at what happened in most communist countries up to now. They have all failed and ended up being eaten up by corruption and laziness (one striking example of this is China... Or not). So, Capitalism in the sense that one will earn according to his efforts works well with us humans. It gives us something to look forward to, a justification for our efforts (just like me writing this blog that no one will ever read).
Unfortunately, it seems to me, that we're about to reach the limits of our capitalistic system. When workers are laid off not because their company is going through hard times but just because their CEO thinks that the shareholders will be happier if the company becomes even more profitable than it already is, the system favors laziness and does not reward hard work. How can you expect to make money by not doing anything? How cool a job is it to be a shareholder? How can we justify letting go of hard working people when lazy people will make money out of it? To me, this is exactly why our system is bound to fail.
So what could we do about it?
Well one idea would be to have every single person on this earth drink Vodka Martinis. This will probably alleviate the burden of knowing that our world is coming to an end.
Another answer would be to try and think of a different or better world order. Why not choose our leaders based on their skills (through a national exam for instance) and not their looks or the promises that they will make and not keep? For this to be possible, we would need to build a system where education is free and everyone gets a chance at excelling through hard work. Wouldn't it make more sense to put the most skilled people at the head of our states? Funny enough, this idea does not sound crazy to me. How about you?
Technocracy does make sense (and I’m not talking about a nation whose national anthem would be a Depeche Mode song).
Click on "comment" below and win a chance to become the next Secretary General of the United Nations.
Thursday, October 14, 2010
How To Deconstruct Your Online Brand And Lower Your Income
Having never read anything about marketing but being the successful author of my blog for almost two weeks, I have decided to declare myself proficient in all matters directly or remotely linked to building an online brand through the extensive use of social networks. Since some of the posts featured in this blog have been read by more than two people (that is at least one other person than myself), I can safely assume that I am on the way (if not yet there) to become a worldwide success(h) (think Tony Montana in Scarface).
Anyway, let me tell you about my experience and what you should do in order to Deconstruct Your Brand and Lower Your Income online:
1) Choose an easy recognizable brand or name for your blog (no more than 2 words with the absolute rule of not using commas or the same word four times in your title). Just look at my blog title and you'll have a perfect example of what was just mentioned.
2) Use your Facebook friends and Twitter followers (if you have any) to increase your blog audience and alienate your friends and followers. This will result in a dramatic loss of Twitter followers and clearly lower your amount of dinner invitations.
3) Maintain a structure: be consistent in what you do. If your aim is to write about various topics that have nothing in common then go ahead and do so! This will get your readers to be bored after one post (in case they stumbled across your blog by accident on a search engine) and they will never come back to your blog.
4) Spend a lot of time writing your blog. This will prevent you from doing anything constructive in your life, like looking after your children, pleasing your spouse or increasing your productivity at your real job. By doing so, you will ensure that no one will ever consider you for a promotion and that your social life will be miserable, hence leaving you with only one option and that is to post even more on your blog.
5) Keep in mind that although some people have made a lot of money online, your chances to make it big time are close to zero and you'd probably be better off playing the lottery.
6) Write in a foreign language to make sure most of your friends won't be interested in reading your blog. In addition, your lack of skills will show in your poor grammar and vocabulary making your style unbearable and your content insipid, therefore annoying any potential reader.
If you have followed all these rules, I am sure you are the third reader of this blog and you should feel free to leave a comment. If you are a man, there is an extra benefit that I forgot to mention: it is that all the stress caused by posting on your blog will lead to an excess release of Cortisol in your bloodstream. This will result, through a complex feedback loop, in a decreased release of Testosterone and should as a consequence shrink your penis of at least one inch (I have experienced this myself).
Labels:
101,
Blog,
Brand,
Cortisol,
Deconstruct,
Expert,
Featured,
Income,
Lower,
Marketing,
Penis,
Proficient,
Shrink,
Size,
Testosterone
Wednesday, October 13, 2010
The American Express Centurion "Black" Card Is For Losers
The much hyped Amex Black Card is for losers! I proudly hold the most precious card ever. It is not black, nor is it made of titanium but it allows me to be treated like royalty at the places I go the most. Whenever I flash this card, people look at me in awe and ask me how to get one. The truth is it is by invitation only. And I consider myself to be one the luckiest guys in the world!
Here is that special VIP card in all its glory:
The 10% discount Burger King Card!
Are you jealous?
Here is that special VIP card in all its glory:
The 10% discount Burger King Card!
Are you jealous?
I Like To Shave My Balls And Wiener
My passion for food isn't limited to hamburgers! I also love Italian food. For most people, Italian food and pizzas might be synonym. But there is a lot more to Italian food than pizzas! As a matter of fact, I recently sampled some delicious meatballs and sausages (pictured above) at Tony's Di Napoli in New York - Times Square. The way I like to eat them is to shave off all the tomato sauce of the sausages (wieners) and meatballs, then add an onion with my fork and a tiny little bit of the aforementioned sauce before eating them! Believe me, the best way to enjoy them is to shave the tomato sauce off!
Labels:
Balls,
Italian Food,
New York,
Sausage,
Shave,
Times Square,
Tony's Di Napoli,
Wiener
Burger King Might Be Coming Back To France
Rumor has it that Burger King might be coming back to France! Their last restaurant in France had closed down in 1997. This Second Coming of the King in France might fulfill my wildest dreams!
If this were to come true, I wouldn't have to use the wormhole that I discovered many years ago. This anomaly in the fabric of the space-time continuum allows me to be at a Burger King in the USA after a 40 mn car drive from France (granted, it's weird that they don't speak English there and that everything is written down in German).
Let's all hail the King when he comes back to France!
Update: this rumor was unfortunately fake.
Tuesday, October 12, 2010
Food For Thought
Labels:
Busy Beaver,
Featured,
Food,
Inspiration,
Number,
Refill,
Thought,
Turing
Warning To Readers Of This Blog
A recent double-blind placebo-controlled study conducted in our reader population showed that reading this blog was associated with a decrease in IQ of 24.42 points in average. As a consequence, this blog is considered to be the most dangerous material ever to be written. Readers must take this fact into consideration before continuing reading it. For readers previously exposed to this blog, it might be too late for them to be able to sanely consider whether or not they should consider prolonging their exposure.
Methodology: both readers and observers were wearing a blindfold in order to ensure the double-blind aspect of this study. Readers wearing their blindfold were then presented with this blog and forced into reading at least one whole article. Observers were also wearing a blindfold and made sure readers completed the task presented to them. The placebo blog used was any other kind of so-called literature.
Conclusion: It is rumored that the conclusion to this study may not be entirely trustworthy as most observers were inadvertently also exposed to this blog.
Summary: Exposure to this blog is extremely dangerous. The author is a living proof of this theory.
Testimonials from our readers:
Robert Xhatan, M.D. from Des Moines, IA: I was a neurosurgeon. After reading this blog, I couldn't find my way back to the hospital where I worked. I am now homeless.
John Doe from Washington, DC: I was a rocket scientist before reading this blog. I am now lost in I dunnoware.
Bob Morane, Indochina: I was seeking the yellow shadow when I stumbled across this blog. I ended up being lost in the infernal valley.
Bill Balantine, Indochina: I second what Bob M. just said.
Civa, Indochina: Where the frack is my necklace?
Maharadjah, Indochina: I have nothing to say.
The Structural Antagonism Between Oral Pleasure And Health
As disappointing as this may sound to the reader, this post is not about oral sex but rather surprisingly about food (another form of oral pleasure). Has it ever occurred to you that most pleasurable food or dishes are usually not good for your health? Whether it is cholesterol-filled tasty sauce or rich nutrients, experiencing fine food at its climax is usually associated with the intrinsic notion of putting our health in a transient state of jeopardy. Refusing to acknowledge this fact can result in an increased risk of cardiovascular or metabolic diseases and hence premature death.
This leads to a rather profound question. Is our world or universe structured in a way that pleasure has to be linked with guilt or danger? Or do we, as human beings, find pleasure in risky behaviors? Should we see in this realization the essence of God or merely the perverted nature of our condition struggling to disavow the castration perpetuated by religion or education? Do we have to sin to experience transient happiness followed by prolonged guilt? Or was our universe so ill-conceived that most good things are bad for us?
Labels:
Antagonism,
Disavowal,
Eudcation,
Featured,
Food,
God,
Mental Health,
Oral,
Oral Sex,
Pleasure,
Rachida Dati,
Religion,
Structural,
Universe
The Case For Food Perversion
I am surprised to see that the concept of Food Perversion is not widely accepted for it is a growing concern for health authorities worldwide. Originating in the structural disavowal of health and nutrition concepts, people suffering from this condition (referred to food perverts in this post) are unable to experience satisfactory gustative pleasure in the absence of their fetish. The most common fetish associated with food perversion is hamburger or melted cheddar cheese. Food perverts will typically only eat meals consisting of hamburgers or anything associated with a melted cheddar cheese sauce. They need to be treated because their condition is associated with an increased risk of cardiovascular and metabolic complications. So let's all raise our voices for food perversion awareness!
Monday, October 11, 2010
My LeWeb'10 Official Blogger Accreditation Application
I've just applied for an official blogger accreditation at the upcoming LeWeb'10 conference! I am in no way hopeful that my application will be accepted but I thought it would be fun to apply (thank you Benoit for the heads-up!). As you might have realized, I'm really into doing things that don't make any sense so applying for an official blogger accreditation really makes sense to me in a nonsensical way.
One thing for sure, I wasn't lying when I stated in my application:
"I will certainly bring a lot of non-sense and humor in my coverage".
I also mentioned that I've been a serious blogger for almost a week!
My Testament Of Faith
I am a true believer in the power of hamburgers. The History Of Hamburgers is my sacred book. Burger King is my temple. Ronald Mc Donald is my guide. Join me in my faith!
Do Potatoes Make Sense?
I recently learned about a new dish called "Potatoes". The way I understand it is that in order to make so-called "Potatoes", one has to stick a lot of French fries together and then wrap them in a brown film so that it makes an ovoid shape. I am outraged by this practice. How could anyone be so senseless and cruel as to use such a beautiful and natural product as fries or cheese fries, strip them of their cheese and stick them together in this manner? In addition, I can't even fathom how disgusting this must taste. It certainly can't be as good as fries which are know to be the second best thing ever just right next to hamburgers. So, if you see potatoes (they should look like the picture below), just run for your life!
The Beauty Of Food Porn
I love to take pictures of food in the wild, i.e. without too much preparation or emphasis on perfection. That is the way it should be done for Beauty lies in the moment. To me, pictures of food surrounded by crumbs on a dirty plate are no more than an attempt at capturing the true essence of what we are as intelligent beings. This food, whether it be hamburgers or cheeseburgers (both being the essential bricks of matter in our universe), ends up in our cells and eventually becomes us. My pictures might be shocking and even qualify as "Food Porn" but they are real. So, if you continue to read this blog, consider this post as a warning and expect a lot more of those in the future.
Labels:
Beauty,
Beings,
Cheeseburgers,
Essence,
Food,
Hamburgers,
Intelligent,
Porn,
True,
Warning
Sunday, October 10, 2010
101010 - 42 - The Ultimate Answer To All Questions
Can there be anything more beautiful in this world than hamburgers? I don't think so! So, let me introduce you to my latest attempt at Burger Heaven: The Big Awesome Burger (B.A.B.) with the works: designed today and hence holding the answer to all questions.
Friday, October 8, 2010
Tourism, Generalization & Anthropology
Our brain is wired to generalize. After experiencing a dangerous situation or a painful stimulus, we tend to avoid similar circumstances thereafter in order to protect ourselves. This phylogenetic cognitive asset, when applied in other areas of our cognitive and behavioral functioning, can however lead to misrepresentation and false beliefs.
As a matter of fact, tourists tend to generalize so much that I do not to believe a word of what they say. Some people will travel abroad for a week and come back home with the absolute confidence that they have profoundly understood a different culture and can tell all their friends about it:
"In xxxx, people are stupid", "In xxxx, people are dirty" or "In xxxx, people are cheap".
How can anyone pretend to have studied a different culture enough in order to make such judgments? In what world do tourists become expert anthropologists during the short span of their vacation? Can you say, after having had a real conversation with, let's be optimistic, 5 different persons that all people in the country are alike? To me, it is no smarter than if I were to go to a local store in my country, talk to someone with whom I might not agree, categorize that person as "stupid", and then go home and say "All people in my country are stupid"? Would that make sense to you? It certainly does not to me.
So please, next time you travel abroad and come back home, try to be a little more modest in the assessment you will make of a different culture. Keep in mind (unless you have a Ph.D. in Anthropology) that you are no expert Anthropologist!
As a matter of fact, tourists tend to generalize so much that I do not to believe a word of what they say. Some people will travel abroad for a week and come back home with the absolute confidence that they have profoundly understood a different culture and can tell all their friends about it:
"In xxxx, people are stupid", "In xxxx, people are dirty" or "In xxxx, people are cheap".
How can anyone pretend to have studied a different culture enough in order to make such judgments? In what world do tourists become expert anthropologists during the short span of their vacation? Can you say, after having had a real conversation with, let's be optimistic, 5 different persons that all people in the country are alike? To me, it is no smarter than if I were to go to a local store in my country, talk to someone with whom I might not agree, categorize that person as "stupid", and then go home and say "All people in my country are stupid"? Would that make sense to you? It certainly does not to me.
So please, next time you travel abroad and come back home, try to be a little more modest in the assessment you will make of a different culture. Keep in mind (unless you have a Ph.D. in Anthropology) that you are no expert Anthropologist!
Thursday, October 7, 2010
My Favorite Podcasts
In this culture shifting day and age, we are not limited by geographical constraints when it comes to watching or listening to our favorite shows! So, here are mine:
- Diggnation: Kevin Rose & Alex Albrecht are potentially hazardous to your health!
- The Endgadget Show: Fantastic gadget coverage by Joshua Topolsky!
- GeekBeat.TV (formerly known as GeekBrief.TV): 5 minute daily gadget news from Cali Lewis!
- TEDTalks: Less than 20 minute expert presentations on various topics ! Amazing concept ! I can't get enough of Ted Talks!
- 2600: Hacker and counterculture podcast! Very informative!
- Naive London Girl: Great audio podcast about sex & relationships ! Anjelika & Wanda are fun to listen to! So is Suzanne Portnoy on her guest star appearances.
- SexGeeks: Discontinued podcast but old episodes are still available for download!
- Diggnation: Kevin Rose & Alex Albrecht are potentially hazardous to your health!
- The Endgadget Show: Fantastic gadget coverage by Joshua Topolsky!
- GeekBeat.TV (formerly known as GeekBrief.TV): 5 minute daily gadget news from Cali Lewis!
- TEDTalks: Less than 20 minute expert presentations on various topics ! Amazing concept ! I can't get enough of Ted Talks!
- 2600: Hacker and counterculture podcast! Very informative!
- Naive London Girl: Great audio podcast about sex & relationships ! Anjelika & Wanda are fun to listen to! So is Suzanne Portnoy on her guest star appearances.
- SexGeeks: Discontinued podcast but old episodes are still available for download!
Labels:
2600,
Alex Albrecht,
Anjelika Jinx,
Cali Lewis,
Culture Shifting,
Diggnation,
Engadget,
Favorite,
GeekBrief.TV,
Kevin Rose,
Naive London Girl,
Podcast,
SexGeeks,
Suzanne Portnoy,
TEDTalks,
Wanda
Wednesday, October 6, 2010
Ode To Absurdism & Numbers
Absurdism refers to the conflict between the human tendency to seek inherent meaning in life and the human inability to find any. I find that true humor lies in the Absurd, at least it is the kind of humor that touches me and lifts me to laughter paradise. I find nothing more exhilarating than The Hitchhiker's Guide To The Galaxy answer to the ultimate question of life, the universe and everything. Who could have constructed a more articulate and elaborate answer than 42 ? What better way to answer the most important philosophical question than to transport it to a whole different plane of understanding and transcend its answer by expressing it in mathematical language? In a similar way, evil forces and the Anti-Christ are also symbolized in western religions by a number (666) for the lack of possible depiction of such a terrifying entity in traditional language.
Psychotic patients often have a singular relationship with language and some feel more comfortable solving mathematical equations than answering simple questions in plain English.
In conclusion, I believe that the true essence of mankind will only find its Xanadu when, in a gravity defying moment, rappers from all over the world unite and shout together : "Yo, 9.81" instead of "Yo, G."
Labels:
42,
666,
9.81,
Anti-Christ,
Constant,
Defying Gravity,
Featured,
g,
Gravity,
Hitch Hiker's Guide To The Galaxy,
Rap,
Wicked
Tuesday, October 5, 2010
Space 1999, Earth 2010 & The Phallic Prosthesis Paradigm

I have always been fascinated by science fiction and even more so by the fact that many technologies or endeavors depicted in this genre end up in the real world (Think Jules Vernes: 20.000 Leagues Under The Sea or From The Earth To The Moon). The Commlock from Space 1999 is no exception to this rule! I was so much looking forward to it becoming a reality when I was a child and I have just realized that my iPhone does a lot more than the Commlock was about! Granted I am no Alphan and we are not close to establishing a colony on the moon! We have, however, developed modern tools that are way ahead of what science fiction envisioned just 30 years ago!
Humans are tool-utilizing animals and our passion for tools (and in a way their phallic prosthesis function) has led us to creating swords, guns and their popular contemporary counterpart: the ubiquitous smartphone.

Monday, October 4, 2010
The Quest For The Perfect Hamburger
My wife and I have recently embarked on a bold journey: the quest for the perfect hamburger.
I feel like a modern times knight wearing a melted-cheese armor, armed with a frying pan riding along a carriage full of hamburger patties. The amount of possible hamburger combinations is just astonishing to me, maybe even more so than the amount of galaxies in the universe or neural connections in the brain. Just try to envision the different types of cheese, temperatures, hamburger patty recipes, types of bun, special sauces, lettuce, tomatoes, onion etc...
The number of combinations is just infinite!
In a way, the quest for the perfect hamburger is akin to the quest for the perfect Dry Martini. I will therefore try and document my advances and discoveries on my blog!
Today's pictures are just the outcome of our attempt at replicating a Juicy Lucy (a Minneapolis specialty)! The beauty of this variation is to actually stuff cheese between 2 hamburger patties, merge them into one prior to frying it.
It was delicious !
Friday, October 1, 2010
Will The Discovery Of Planet Zarmina (Gliese 581g) Change Our Faith?
The discovery of Planet Zarmina (Gliese 581g) is a ground breaking moment in human history. For the first time ever, we have reasonable proof that another Planet than earth in a not-so-distant Solar System could support human life. This only can lead to the conclusion that there probably is an astonishing amount of planets similar to earth in the Universe. Therefore, it must be very likely that life exists beyond our blue horizons.
Although I am thrilled by this discovery, I can hardly fathom the perhaps not-so-distant day when we discover life or, even better, intelligent life outside of our solar system. The world will be profoundly shaken and hopefully come to the realization that all our earthly conflicts have zero significance at the scale of the Universe. How will earthlings integrate this discovery with the religions they have believed in for centuries? How can we fight on earth over whose God is right when life is not limited to our planet?
Will we discover that Prophets visited other planets as well ? Or for the lack of such a fact, will we join our faiths and those of aliens in a common belief or understanding of an almighty essence in the Universe?
Can The Panspermia Theory (or as I like to call it: The Cosmic Bukkake Theory) explain a single origin of life in the entire Universe? I highly doubt it. So, if life emerged on different planets, at different times, under different (or why not the same) forms, shouldn't this come into conflict with our earthly faiths?
It certainly does not answer the question of God but it might bring us closer to it.
Labels:
Aliens,
Bukkake,
Cosmic,
E.T.,
Gliese 581g,
Life,
Panspermia,
Peace,
Religion,
Solar System,
Theology,
Zarmina
Monday, September 13, 2010
The Rise Of The Placebo Response In CNS Clinical Trials
There has been a lot of controversy recently about the rise of the Placebo response in recent Central Nervous System (CNS) clinical trials. Many of these trials failed to show statistically different responses between new treatments and Placebos. It seems that the Placebo Response in CNS trials has never been as high in the past and it is becoming more and more important.
Many people have tried to figure out why, some almost going to the extent of seeing some kind of mystical explanation to it. The most common and accepted explanation is to say that clinical investigators are becoming less and less experienced and are responsible for this. The theory is that if an investigator is too empathetic during a clinical trial, they might trigger a higher Placebo Response in the subject. In addition, if the investigator is not properly trained they might be responsible for inaccurate assessments.
I believe that the explanation is actually easier to figure out. As a clinical investigator myself, some might say that I am biased but I also believe myself to be more knowledgeable than mot people about this subject since I am writing about something I experience first hand.
It is my strong belief that the rise of the Placebo Response in recent CNS clinical trials is due to the rise of regulatory and legal pressure. Let me explain this. Pharmaceutical companies are responsible for the clinical trials that they conduct (investigators too of course). Regulatory agencies put a lot of pressure on Pharmaceutical Companies to prove the efficacy of their new treatments. Statistically speaking, if you want to prove the efficacy of a new agent, you have to conduct trials v. placebo and v. the most up-to-date treatment used in the same indication. In order to do so, subjects enrolled in clinical trials have to be "perfect" in the sense that the less concomitant medical condition and treatment they have the better. Following this logic, subjects enrolled in antidepressant trials seldom suffer from any other medical condition, they are not allowed to take other medicine for anxiety or sleeping disorder and most importantly they won't enter the trial if they have suicidal ideations.
This is where the explanation lies: the most severely depressed patients all have suicidal ideations, they all suffer from severe insomnia and anxiety that would require concomitant treatment. Therefore, they wouldn't be enrolled in CNS clinical trials. The only consequence to this is that only less severely depressed patients are enrolled in clinical trials and they are the ones that are the most likely to show Placebo response.
I understand that in order to statistically prove the efficacy of a new agent, it has to be taken by patients with no other concomitant medication. However, the reality is that enhancing to statistical "beauty" of a trial by not allowing concomitant medication leads to enrolling patients that are not heterogenous enough to differentiate the new agent from the Placebo.
In addition, pharmaceutical companies don't want investigators to enroll patients that are at suicidal risks because the legal consequences of a suicide would be devastating. Once again, I understand their reasons but the reality is that it leads to enrolling less severely depressed patients in CNS clinical trials, therefore leading to a higher rate of Placebo responders.
Authorities and Pharmaceutical Companies really need to consider this in the future before they start putting the blame on investigators that, on top of everything, are probably better trained than ever before. In essence, when pharmaceutical companies say that investigators are responsible for the rise of the Placebo Response, they are admitting that patients enrolled in their trials are very likely to show Placebo Response and it has been know for a very long time, that depressed patients very likely to react to external circumstances are usually the least severely depressed ones, hence proving my point!
Friday, June 11, 2010
Freud, Einstein, The Universe, Quantum Teleportation & The Future of IT
It turns out that I've been very been much interested in Quantum Mechanics lately. This isn't a new hobby of mine as I remember, when I was in High School, having a hard time deciding which studies I wanted to pursue. The fascinating world of Quantum Mechanics as well as my long interest in Astrophysics seemed as important to me as the exhilarating psychoanalytic theories of Freud.
If I had to name the most significant scientific figures of the 20th century, I would without any hesitation mention Albert Einstein & Sigmund Freud. They have both uncovered new fields of science and had the audacity and courage to question the established knowledge.
I can't help thinking that there are still great discoveries to be made and that our knowledge of the fabric of space and time is still very limited, probably in the same way that our understanding of consciousness is. My recent post about microtubules & consciousness shows that the world of Quantum Physics and the world of Biology are about to collide and maybe lead to a better understanding of who and what we are.
As for Quantum Mechanics & geekier concerns, I recently stumbled accross this news:
Scientists were able to successfully teleport information between 2 entangled photons across a ten-mile distance! This is an absolute great achievement and when you think of it, it might pave the way for unlimited bandwidth over unlimited distances! Imagine an Internet not limited by bandwidth concerns!
Thursday, June 3, 2010
Microtubules & Consicousness
Taking into consideration the possible role of microtubules in the consciousness process in humans relegates the advent of the singularity (i.e. consciousness of computer networks) to a much later date than anticipated since the amount of processed information is much bigger than ever thought !
Stuart Hameroff wrote a fascinating theory of consciousness involving quantum mechanics & microtubules in neurons.
Wednesday, April 14, 2010
We Are What We Code
The advent of social media certainly has changed the way we use computers and cell phones and I do believe that our lives also have been changed as a result. Some might argue that many of use have become addicted to the Internet and computers in general. My previous posts on this blog clearly show that I don't subscribe to this point of view.
We humans use tools and are social animals. That is what differentiates us from animals. The Internet & the social media revolutions simply have empowered us with new tools that we are starting to tame.
We, however, should not forget that tools have the power to free but also enslave us. Many corporate IT systems actually have led to enslaving and limiting workers and it has become all the more clear in recent years that many IT systems are so ill-conceived that they make customers and workers lose precious time when they should actually help them save time.
There is a growing need in IT efficiency that needs to be addressed and IT managers should be aware that not every system is efficient per se. They should always be confronted with the reality of everyday use and practical thinking.
Tuesday, February 9, 2010
The Internet Addiction Urban Legend
This post aims at addressing the concept of Internet addiction. As a psychiatrist, I'm baffled to read articles written by fellow psychiatrists (usually the ones that have never used a computer in their entire life) emphasizing the dangers of Internet addiction.
To me, they just don't get it. The Internet is a medium. There is no such thing as being addicted to it. You can certainly be addicted to some online games or say, online porn. But, to me, talking about Internet addiction is, simply put, the proof that the person talking don't know what they're talking about. Many psychiatrists have applied the DSM-IV ("Psychiatry Bible") addiction criteria to the Internet to give birth to the concept of "Internet addiction". To me, it is as stupid as writing about breathing addiction (aren't we all addicted to breathing air? We can't spend a single day without doing it) or feeding addiction (we all feel the urge to eat whenever we've been deprived of food for a few hours...). The same could apply to "reading addiction".
Once again, the Internet is a medium. You can do thousands of different things online. Spending hours in front of a computer doesn't mean that you're addicted to doing the same thing as you can do so many different things on the Internet. People, specially mental health professionals, need to understand this paradigm shift.
To me, they just don't get it. The Internet is a medium. There is no such thing as being addicted to it. You can certainly be addicted to some online games or say, online porn. But, to me, talking about Internet addiction is, simply put, the proof that the person talking don't know what they're talking about. Many psychiatrists have applied the DSM-IV ("Psychiatry Bible") addiction criteria to the Internet to give birth to the concept of "Internet addiction". To me, it is as stupid as writing about breathing addiction (aren't we all addicted to breathing air? We can't spend a single day without doing it) or feeding addiction (we all feel the urge to eat whenever we've been deprived of food for a few hours...). The same could apply to "reading addiction".
Once again, the Internet is a medium. You can do thousands of different things online. Spending hours in front of a computer doesn't mean that you're addicted to doing the same thing as you can do so many different things on the Internet. People, specially mental health professionals, need to understand this paradigm shift.
Friday, February 5, 2010
Qantas Of Solace
Yesterday, I thought about this geeky thing that happened to me 6 months ago.
It was a rather cold morning in Sydney, Australia last August. I happened to be riding on a hop-on hop-off, double decker open top city-tour bus when when my iPhone received a push email that was sent in the middle of the night just seconds ago in France. That email came from a patient of mine who was facing a personal crisis. It was long but I was able to read it entirely on my iPhone while riding on the open upper deck of this city tour bus.
I couldn't help but experience a rather awkward and disturbing feeling. The contrast between this email sent by someone desperate on the other side of the planet, in the middle of a summer night, and me receiving it, during a happy moment as far as I could be from home, in the morning in winter. This was rather unsettling and reminded me of the new technology-enhanced world we are all living in.
I was hopefully able to answer this email within minutes with a few comforting words that brought solace to this patient who still has no clue where I was at the moment I answered!
This can only lead to one question:
1) What kind of crazy world are we living in?
2) What kind of crazy/geeky shrink am I in this world?
Subscribe to:
Posts (Atom)